Current theories of knowledge, art, and power are locked into sterile debates around the question of representation. This book examines the limits of antirepresentationalism in these fields and argues that the anarchist tradition can point the way beyond our contemporary crisis of representation. The author rereads the theory and practical experiences of anarchism from the nineteenth century to the present, proposing a radical revision of received notions of the subject - from the equation of anarchy with literary decadence to the (...) interpretation of anarchism as yet another discourse founded on a notion of the human essence. What emerges, instead, is a complex portrait of anarchism as a body of thought that provides the framework for a kind of critical realism, with implications for fields ranging from aesthetics to economics, from philosophy to politics. Jesse Cohn teaches English at Purdue University North Central. (shrink)

This paper surveys some of the questions that arise when we consider how entanglement and relativity are related via the notion of non-locality. We begin by reviewing the role of entangled states in Bell inequality violation and question whether the associated notions of non-locality lead to problems with relativity. The use of entanglement and wavefunction collapse in Einstein's famous incompleteness argument is then considered, before we go on to see how the issue of non-locality is transformed if one considers quantum (...) mechanics without collapse to be a complete theory, as in the Everett interpretation. (shrink)

Experiential evidence shows that pain is associated with common meanings. These include a meaning of threat or danger, which is experienced as immediately distressing or unpleasant; cognitive meanings, which are focused on the long-term consequences of having chronic pain; and existential meanings such as hopelessness, which are more about the person with chronic pain than the pain itself. This interdisciplinary book - the second in the three-volume Meanings of Pain series edited by Dr Simon van Rysewyk - aims to better (...) understand pain by describing experiences of pain and the meanings these experiences hold for the people living through them. The lived experiences of pain described here involve various types of chronic pain, including spinal pain, labour pain, rheumatic pain, diabetic peripheral neuropathic pain, fibromyalgia, complex regional pain syndrome, endometriosis-associated pain, and cancer-related pain. Two chapters provide narrative descriptions of pain, recounted and interpreted by people with pain. Language is important to understanding the meaning of pain since it is the primary tool human beings use to manipulate meaning. As discussed in the book, linguistic meaning may hold clues to understanding some pain-related experiences, including the stigmatisation of people with pain, the dynamics of patient-clinician communication, and other issues, such as relationships between pain, public policy and the law, and attempts to develop a taxonomy of pain that is meaningful for patients. Clinical implications are described in each chapter. This book is intended for people with pain, their family members or caregivers, clinicians, researchers, advocates, and policy makers. (shrink)

David Brown (b. 1948) is a Scottish Episcopal priest and theologian whose work covers a vast terrain spanning methodological divisions between philosophy, Christian theology, religious studies, the arts and culture. Early work on the Trinity and Incarnation led to a Newman-inspired articulation of Scripture as tradition, and, related to this, the exploration of tradition as revelation with reference to a wide range of human experience. Moving from materially-mediated divine presence to culturally-mediated revelation, Brown's phenomenology of religious experience amounts to a (...) transformed natural religion along sacramental lines. Essays in this volume consider Brown's wide ranging and generative contributions in three parts: 1) Butler & Newman, 2) Incarnation & Trinity, and 3) Sacramentality & the Arts, with a concluding response from Brown himself that addresses 'religious experience and revelation', as well as 'secular culture and religious distinctiveness'. (shrink)

Department of Philosophy Brown University Providence, RI 02912.

Department of Philosophy Brown University Providence, RI 02915.

The negative emotions generated following stressful life events can increase one’s risk of depressive symptoms and promote higher levels of perceived stress. The process model of emotion regulation can help distinguish between adaptive and maladaptive emotion regulation strategies to determine who may be at the greatest risk of worse psychological health across the lifespan. Heart rate variability may affect these relationships as it indexes aspects of self-regulation, including emotion and behavioral regulation, that enable an individual to dynamically adapt to the (...) changing demands of both internal and external environments. In this study, we expected individual differences in resting vagally mediated HRV to moderate the influence of emotion regulatory strategies among our sample of 267 adults. We found support for the hypothesis that higher vagally mediated HRV buffers against the typical adverse effects of expressive suppression when evaluating depressive symptoms and found weak support when considering perceived stress. There was no evidence for an interaction between cognitive reappraisal and vagally mediated HRV but there was a significant, negative association between cognitive reappraisal and depressive symptoms and perceived stress. Future work may determine if intervening on either emotion regulation strategies or HRV may change these within-persons over time. (shrink)

Précis of Consciousness Content Type Journal Article Pages 1-5 DOI 10.1007/s11098-011-9813-3 Authors Christopher S. Hill, Department of Philosophy, Brown University, Providence, RI 02912, USA Journal Philosophical Studies Online ISSN 1573-0883 Print ISSN 0031-8116.

Reply to Alex Byrne and Fred Dretske Content Type Journal Article Pages 1-9 DOI 10.1007/s11098-011-9814-2 Authors Christopher S. Hill, Department of Philosophy, Brown University, Providence, RI 02912, USA Journal Philosophical Studies Online ISSN 1573-0883 Print ISSN 0031-8116.

Written memoranda of conversations, or memcons, provide a near‐contemporaneous record of what was said in conversation, and offer important insights into the activities of high‐profile individuals. We assess the impact of writing a memcon on memory for conversation. Pairs of participants engaged in conversation and were asked to recall the contents of that conversation 1 week later. One participant in each pair memorialized the content of the interaction in a memcon shortly after the conversation. Participants who generated memcons recalled more (...) details of the conversations than participants who did not, but the content of recall was equally and largely accurate for both participants. Remarkably, only 4.7% of the details of the conversation were recalled by both of the partners after a week delay. Contemporaneous note‐taking appears to enhance memory for conversation by increasing the amount of information remembered but not the accuracy of that information. These findings have implications for evaluating the testimony of participants on conversations with major political or legal ramifications. (shrink)

In recent months, pharmaceutical manufacturers have brought legal challenges to a provision of the 2022 Inflation Reduction Act (IRA) empowering the federal government to negotiate the prices Medicare pays for certain prescription medications. One key argument made in these filings is that price negotiation is a “taking” of property and violates the Takings Clause of the US Constitution. Through original case law and health policy analysis, we show that government price negotiation and even price regulation of goods and services, including (...) patented goods, are constitutional under the Takings Clause. Finding that the IRA violates the Takings Clause would radically upend settled constitutional law and jeopardize the US’s most important state and federal health care programs. (shrink)

Jaegwon Kim maintains that his ‘exclusion argument’ forces us to accept reductive physicalism, which identifies mental and other high-level properties of the world with lower-level properties, over nonreductive physicalism, which avoids such identifications. According to Kim, the exclusion argument shows that any nonreductive view leads to either epiphenomenalism or unacceptable overdetermination of physical effects by physical causes. However, a popular nonreductive physicalist approach called ‘compatibilism’ aims to show that physicalism need not collapse high-level properties into lower-level physical. Compatibilism attempts to (...) block the exclusion argument by attending to the tight modal relationship between higher and lower properties required by nonreductive physicalism. Unfortunately, a similarly tight modal relationship will be embraced by any dualists who hold that natural laws are metaphysically necessary. Despite its increasingly widespread popularity among nonreductive physicalists, it thus seems that the compatibilist’s proposed solution cannot be upheld without removing the barriers to dualists of this sort. (shrink)

Russellian physicalism has the promise of answering all the typical challenges that non-physicalists have issued against standard versions of physicalism, while not giving up physicalism's commitment to the non-existence of fundamental mentality. However, it has been argued that Russellian physicalism must endorse the existence of physically unacceptable protomental properties in order to address these challenges, which would mean giving up on a core physicalist tenet of keeping the fundamental realm untainted by a special relationship to mentality. Against this, I argue (...) that a plausible version of Russellian physicalism can be constructed, which does not posit fundamental properties that are at all protomental in any problematic sense, yet which can explain the existence of subjective experience. This non-protomental Russellian physicalism, which is the only properly-physical version of Russellian physicalism, offers a satisfying solution to the mind-body problem -- including an answer to the conceivability argument -- without sacrificing any of its physicalist credentials. (shrink)

I do four things in responding to Patrick Toner’s incisive critique of my Aquinas and the Ship of Theseus (AST). First, I further motivate Aquinas’s position that Socrates exists in the post-mortem and ante-resurrection state by noting that Socrates’ situation is at least analogous to other states of affairs that would certainly count as atypical (although not impossible). Secondly, I offer a revised Thomistic account of artefact identity through time in light of Toner’s objections to Aquinas’srestrictive view. Unlike the restrictive (...) view, this revised account is compatible with common-sense intuitions. Thirdly, I show how my defense of Aquinas’s substance metaphysic in AST is useful for the purpose of constructing defeators for certain kinds of arguments for reductionism. Fourthly, I defend Aquinas’s views on the unity of substance against Toner’s suggestion that they are implausible on the grounds that they are in conflict with certain so-called “scientifically informed”common-sense beliefs. (shrink)

I do four things in responding to Patrick Toner’s incisive critique of my Aquinas and the Ship of Theseus (AST). First, I further motivate Aquinas’s position that Socrates exists in the post-mortem and ante-resurrection state by noting that Socrates’ situation is at least analogous to other states of affairs that would certainly count as atypical (although not impossible). Secondly, I offer a revised Thomistic account of artefact identity through time in light of Toner’s objections to Aquinas’srestrictive view. Unlike the restrictive (...) view, this revised account is compatible with common-sense intuitions. Thirdly, I show how my defense of Aquinas’s substance metaphysic in AST is useful for the purpose of constructing defeators for certain kinds of arguments for reductionism. Fourthly, I defend Aquinas’s views on the unity of substance against Toner’s suggestion that they are implausible on the grounds that they are in conflict with certain so-called “scientifically informed”common-sense beliefs. (shrink)

In a comparison of the principles of special relativity and of quantum mechanics, the former theory is marked by its relative economy and apparent explanatory simplicity. A number of theorists have thus been led to search for a small number of postulates - essentially information theoretic in nature - that would play the role in quantum mechanics that the relativity principle and the light postulate jointly play in Einstein's 1905 special relativity theory. The purpose of the present paper is to (...) resist this idea, at least in so far as it is supposed to reveal the fundamental form of the theory. It is argued that the methodology of Einstein's 1905 theory represents a victory of pragmatism over explanatory depth; and that its adoption only made sense in the context of the chaotic state state of physics at the start of the 20th century - as Einstein well knew. (shrink)

Between 1964 and 1990, the notion of nonlocality in Bell's papers underwent a profound change as his nonlocality theorem gradually became detached from quantum mechanics, and referred to wider probabilistic theories involving correlations between separated beables. The proposition that standard quantum mechanics is itself nonlocal became divorced from the Bell theorem per se from 1976 on, although this important point is widely overlooked in the literature. In 1990, the year of his death, Bell would express serious misgivings about the mathematical (...) form of the local causality condition, and leave ill-defined the issue of the consistency between special relativity and violation of the Bell-type inequality. In our view, the significance of the Bell theorem, both in its deterministic and stochastic forms, can only be fully understood by taking into account the fact that a fully Lorentz-covariant version of quantum theory, free of action-at-a-distance, can be articulated in the Everett interpretation. (shrink)

I do four things in responding to Patrick Toner’s incisive critique of my Aquinas and the Ship of Theseus (AST). First, I further motivate Aquinas’s position that Socrates exists in the post-mortem and ante-resurrection state by noting that Socrates’ situation is at least analogous to other states of affairs that would certainly count as atypical (although not impossible). Secondly, I offer a revised Thomistic account of artefact identity through time in light of Toner’s objections to Aquinas’srestrictive view. Unlike the restrictive (...) view, this revised account is compatible with common-sense intuitions. Thirdly, I show how my defense of Aquinas’s substance metaphysic in AST is useful for the purpose of constructing defeators for certain kinds of arguments for reductionism. Fourthly, I defend Aquinas’s views on the unity of substance against Toner’s suggestion that they are implausible on the grounds that they are in conflict with certain so-called “scientifically informed”common-sense beliefs. (shrink)

One important part of Aquinas’s theory of the nature of corruptible corporeal substances is his account of the individuation of such entities. In this paper, I examine an aspect of Aquinas’s account of individuation that has not received as much attention as some others, namely, how Aquinas applies his account of individuation specifically to cases involving non-living corporeal substances. I first offer an interpretation of a key passage in Aquinas’s corpus where he explains his theory of individuation. Second, I examine (...) a text where Aquinas applies his account of individuation to a case involving non-living substances. Finally, I raise a possible objection to what Aquinas says about the individuation of non-living substances and in answering the objection suggest that Aquinas holds the view that non-living substances enjoy a less perfect mode of individuality when compared to living substances. (shrink)

In a recent paper, “Incompatiblism, Sin, and Free Will in Heaven,” Timothy Pawl and Kevin Timpe discuss and propose a novel solution to a problem posed for traditional Christian theism that they call the Problem of Heavenly Freedom. In short, Christian tradition contains what seems to be a contradiction, namely, the redeemed in heaven are free but nonetheless can’t sin. Pawl and Timpe’s solution to the Problem of Heavenly Freedom is particularly attractive for two reasons: it shows great respect for (...) the Christian tradition’s teaching on heaven, and it entails that the redeemed in heaven act with morally weighty libertarian free will. Nonetheless, I think their solution can be improved upon. By drawing on some of the teachings of the Catholic tradition on heaven, particularly those of St. Thomas Aquinas, I raise three objections to Pawl and Timpe’s solution and introduce a modified version of their solution. In doing so, I have attempted to make their “best” solution to the Problem of Heavenly Freedom even better. (shrink)

This chapter outlines the utility for employing case study methodologies to provide sufficient external validity upon which to craft policy relevant to maintaining healthy democratic politics. The broader theoretical context is an investigation into the conditions that might structurally condition democracies to fail via democratic means. Venezuela’s democratic decline serves as the basis for the heuristic case study, wherein the objective is to identify the failures of the Venezuelan case in a larger framework that addresses the complexity of institutional design (...) in democratic political systems states broadly. Cases are selected based upon the objective of the researcher, and similarly, the case study methodology chosen rests firmly on their research goals. Lastly, the chapter outlines the research design necessary for satisfying broader inquiry within the more modest approach to how heuristic case studies can be used to inform both theory and policy. (shrink)

In The Years of Extermination, the second volume of Nazi Germany and the Jews, Saul Friedländer attempts to write an “integrated” history of the Holocaust that captures the “convergence” of German decisions and policies, the reaction of the surrounding world, and the perceptions and experiences of the Jews. Although several historiographical issues are studied in detail , the most innovative aspect of the book is its extensive use of excerpts from over forty diaries of Jewish victims, which are interspersed among (...) the statements of Nazi leaders and officials, Wehrmacht soldiers, churchmen, and various collaborators and bystanders in order to juxtapose “entirely different levels of reality.” What ultimately holds the book together, despite its intentionally disrupted narrative and Friedländer’s disclaimer that the history of the Holocaust can be encompassed within any “single conceptual framework,” is the overarching theme of the “crisis of liberalism.”. (shrink)

It is well known that in early Greek epic old age was something that could be scraped off a man, and it is the purpose of this note to explore the image and to suggest a possible origin. The idea is first attested in a counterfactual conditional sentence in Phoenix's speech atIl.9.445–6: ‘nor even if [a god] himself were to undertake to render me young and flourishing after scraping off old age …’ ; in a description of Medea's magical rejuvenation (...) of Aeson in theNostoi; and in the account of Eos' botched attempt to make Tithonus immortal in theHomeric Hymn to Aphrodite:οὐδ' ἐνόησε μετὰ ϕρεσὶ πότνια Ἠώςἥβην αἰτῆσαι, ξῦσαί τ' ἄπο γῆρας ὀλοιόν.Nor did lady Dawn think in her mind to ask for youth and to scrape off ruinous old age.This language also occurs in Late Antiquity, and Andrew Faulkner in his commentary on theHymn cites Greg. Nanz.Carm.1.2.2.483 in the fourth centurya.d.and the much later Cometas,Anth. Pal.15.37.2. So far as the imagery implicit in these passages is concerned, S. D. Olson writes, ‘old age is imagined as a scurf or patina that can be scoured off a person’. Faulkner, however, prefers a more precise reference: ‘Griffin … relates it to the idea of old age as a skin that can be shed, as that of a snake’, and he helpfully cites Theodoros Prodromos,Carmina historica24.18, ἀπόξυσαι τὸ γῆρας ὥσπερ ὄϕις. (shrink)

One important part of Aquinas’s theory of the nature of corruptible corporeal substances is his account of the individuation of such entities. In this paper, I examine an aspect of Aquinas’s account of individuation that has not received as much attention as some others, namely, how Aquinas applies his account of individuation specifically to cases involving non-living corporeal substances. I first offer an interpretation of a key passage in Aquinas’s corpus where he explains his theory of individuation. Second, I examine (...) a text where Aquinas applies his account of individuation to a case involving non-living substances. Finally, I raise a possible objection to what Aquinas says about the individuation of non-living substances and in answering the objection suggest that Aquinas holds the view that non-living substances enjoy a less perfect mode of individuality when compared to living substances. (shrink)

BackgroundOne of the next frontiers in HIV research is focused on finding a cure. A new priority includes people with HIV (PWH) with non-AIDS terminal illnesses who are willing to donate their bodies at the end-of-life (EOL) to advance the search towards an HIV cure. We endeavored to understand perceptions of this research and to identify ethical and practical considerations relevant to implementing it.MethodsWe conducted 20 in-depth interviews and 3 virtual focus groups among four types of key stakeholders in the (...) United States (PWH, biomedical HIV cure researchers, HIV clinicians, and bioethicists) to obtain triangulated viewpoints because little was known about the ethics of this topic. Each group was queried as to ethical considerations, safeguards, and protections for conducting HIV cure-related research at the EOL to ensure this research remains acceptable.ResultsAll four key stakeholder groups generally supported HIV cure-related research conducted at the EOL because of the history of altruism within the PWH community and the potential for substantial scientific knowledge to be gained. Our informants expressed that: (1) Strong stakeholder and community involvement are integral to the ethical and effective implementation, as well as the social acceptability of this research; (2) PWH approaching the EOL should not inherently be considered a vulnerable class and their autonomy must be respected when choosing to participate in HIV cure-related research at the EOL; (3) Greater diversity among study participants, as well as multi-disciplinary research teams, is necessitated by HIV cure-related research at the EOL; (4) The sensitive nature of this research warrants robust oversight to ensure a favorable risk/benefit balance and to minimize the possibility of therapeutic misconception or undue influence; and (5) Research protocols should remain flexible to accommodate participants’ comfort and needs at the EOL.ConclusionBecause of the ethical issues presented by HIV cure-related research at the EOL, robust ethical safeguards are of utmost importance. The proposed ethical and practical considerations presented herein is a first step in determining the best way to maximize this research’s impact and social value. More much inquiry will need to be directed towards understanding context-specific and cultural considerations for implementing EOL HIV cure research in diverse settings. (shrink)

Few think that Kant’s moral theory can provide a defensible view in the area of environmental ethics because of Kant’s well-known insistence that all nonhumans are mere means. An examination of the relevant arguments, however, shows that they do not entitle Kant to his position. Moreover, Kant’s own Formula of Universal Law generates at least one important and basic duty which is owed both to human beings and to nonhuman animals. The resulting Kantian theory not only is sounder and more (...) intuitive than the original, but also boasts some notable theoretical advantages over some of the most prominent views in environmental ethics. (shrink)

In Frogs Aristophanes presents the comic katabasis of Dionysus, whose quest is to bring back the recently deceased Euripides and restore him to the Athenian literary scene. In the prologue Dionysus and his slave, Xanthias, seek out Heracles and ask his advice about the journey below. After some comic play, as they consider various short-cuts, Heracles finally gives Dionysus a serious lesson in Underworld geography . The various items on this itinerary – Charon, terrifying beasts, filth and excrement, sinners, μσται (...) – are all encountered on Dionysus' journey, each transformed for humorous effect. Dionysus crosses the lake on Charon's barque, but is forced to row . At this point we have the introduction of the off-stage chorus that gives the play its name. In what appears to be a kind of false parodos Dionysus engages in a metrical tug-of-war with the frogs that finally spoils his rowing rhythm. After disembarking, he is joined by Xanthias, who was forced to walk around the lake, and they find themselves in the place of σκτος κα βρβορος , where they see the miscreants . In place of εις and θηρα μυρα δειτατα , our heroes are terrified by the figure of Empousa, who is seen by Xanthias alone . When Empousa is gone, there appears the chorus of initiates, whose song constitutes the parodos. (shrink)

The article analyzes the peculiarities of the destruction of Serbian Jews during Second Wolrd War in the local and European context. Of all the sites in Serbia relevant to the destruction of the Serbian Jews, Sajmiste is the most important. After the consideration of the attitude of Germans and Nedic?s regime toward Jews and?Gypsies? in the context of the Final Solution, the author highlights that the Sajmiste internment camp was transformed into a local death camp-the only such site outside the (...) territories of Poland and the Soviet Union. Serbia was the one country outside Poland and the Soviet Union where all Jewish victims were killed on the spot without deportation. It was the first country after Estonia to be declared?judenfrei.? Moreover, in Serbia the German army was not only complicit in the Holocaust but was in fact the main instigator and executioner in the killing of the Jewish men. For this reason, in particular, Sajmiste is a unique site for Holocaust remembrance not only in the Serbian but also in the European context. Clanak analizira osobenosti unistenja srpskih Jevreja tokom Drugog svetskog rata u lokalnom i evropskom kontekstu. Od svih mesta u Srbiji koja su relevantna za unistenje Jevreja, Sajmiste je najvaznije. Nakon razmatranja stava Nemaca i Nedicevog rezima prema Jevrejima i?Ciganima?, autor istice da je od logora za internaciju, Sajmiste transformisano u lokalni logor smrti, jedini takav izvan teritorija Poljske i Sovjetskog Saveza: osim Poljske i Sovjetskog Saveza, Srbija je jedina zemlja gde su jevrejske zrtve ubijane na licu mesta, bez deportacije. Posle Estonije, prva je zemlja koja je proglasena za judenfrei. Stavise, u Srbiji nemacka vojska bila je ne samo saucesnik u Holokaustu vec i glavni podstrekac i izvrsilac ubijanja Jevreja. Posebno zbog ovih razloga, Sajmiste predstavlja jedinstveno mesto secanj? na Holokaust, ne samo u srpskom vec i u evropskom kontekstu. (shrink)

This chapter contains sections titled: The Kantian Gate Dating as Flow and Cultivated Spontaneity.

BackgroundThe ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines are widely endorsed but compliance is limited. We sought to determine whether journal-requested completion of an ARRIVE checklist improves full compliance with the guidelines.MethodsIn a randomised controlled trial, manuscripts reporting in vivo animal research submitted to PLOS ONE (March–June 2015) were randomly allocated to either requested completion of an ARRIVE checklist or current standard practice. Authors, academic editors, and peer reviewers were blinded to group allocation. Trained reviewers performed outcome adjudication (...) in duplicate by assessing manuscripts against an operationalised version of the ARRIVE guidelines that consists 108 items. Our primary outcome was the between-group differences in the proportion of manuscripts meeting all ARRIVE guideline checklist subitems.ResultsWe randomised 1689 manuscripts (control: n = 844, intervention: n = 845), of which 1269 were sent for peer review and 762 (control: n = 340; intervention: n = 332) accepted for publication. No manuscript in either group achieved full compliance with the ARRIVE checklist. Details of animal husbandry (ARRIVE subitem 9b) was the only subitem to show improvements in reporting, with the proportion of compliant manuscripts rising from 52.1 to 74.1% (X2 = 34.0, df = 1, p = 2.1 × 10−7) in the control and intervention groups, respectively.ConclusionsThese results suggest that altering the editorial process to include requests for a completed ARRIVE checklist is not enough to improve compliance with the ARRIVE guidelines. Other approaches, such as more stringent editorial policies or a targeted approach on key quality items, may promote improvements in reporting. (shrink)

I. EXECUTIVE SUMMARY The MRCT Center Post-trial Responsibilities: Continued Access to an Investigational Medicine Framework outlines a case-based, principled, stakeholder approach to evaluate and guide ethical responsibilities to provide continued access to an investigational medicine at the conclusion of a patient’s participation in a clinical trial. The Post-trial Responsibilities (PTR) Framework includes this Guidance Document as well as the accompanying Toolkit. A 41-member international multi-stakeholder Workgroup convened by the Multi-Regional Clinical Trials Center of Brigham and Women’s Hospital and Harvard University (...) (MRCT Center) developed this Guidance and Toolkit. Project Motivation A number of international organizations have discussed the responsibilities stakeholders have to provide continued access to investigational medicines. The World Medical Association, for example, addressed post-trial access to medicines in Paragraph 34 of the Declaration of Helsinki (WMA, 2013): “In advance of a clinical trial, sponsors, researchers and host country governments should make provisions for post-trial access for all participants who still need an intervention identified as beneficial in the trial. This information must also be disclosed to participants during the informed consent process.” This paragraph and other international guidance documents converge on several consensus points: • Post-trial access (hereafter referred to as “continued access” in this Framework [for terminology clarification – see definitions]) is the responsibility of sponsors, researchers, and host country governments; • The plan for continued access should be determined before the trial begins, and before any individual gives their informed consent; • The protocol should delineate continued access plans; and • The plan should be transparent to potential participants and explained during the informed consent process. -/- However, there is no guidance on how to fulfill these responsibilities (i.e., linking specific responsibilities with specific stakeholders, conditions, and duration). To fill this gap, the MRCT Center convened a working group in September of 2014 to develop a framework to guide stakeholders with identified responsibilities. This resultant Framework sets forth applicable principles, approaches, recommendations and ethical rationales for PTR regarding continued access to investigational medicines for research participants. (shrink)

Background While prenatal surgery historically was performed exclusively for lethal conditions, today intrauterine surgery is also performed to decrease postnatal disabilities for non-lethal conditions. We sought to describe physicians' attitudes about prenatal surgery for lethal and non-lethal conditions and to elucidate characteristics associated with these attitudes. Methods Survey of 1200 paediatric surgeons, neonatologists and maternal–fetal medicine specialists. Results Of 1176 eligible physicians, 670 responded. In the setting of a lethal condition for which prenatal surgery would likely result in the child (...) surviving with a severe disability, most respondents either disagreed or strongly disagreed that they would recommend the surgery. Male physicians were twice as likely to recommend surgery for the lethal condition, as were physicians who believe that abortion is morally wrong. Older physicians were less likely to recommend surgery. For non-lethal conditions, most respondents agreed that they would recommend prenatal surgery, even if the surgery increases the risk of prematurity or fetal death. Compared with MFMs, surgeons were less likely to recommend such surgery, as were physicians not affiliated with a fetal centre, and physicians who were religious. Conclusion Physician’s attitudes about prenatal surgery relate to physicians’ beliefs about disability as well as demographic, cultural and religious characteristics. Given the variety of views, parents are likely to receive different recommendations from their doctors about the preferable treatment choice. (shrink)

In Laws and Lawmakers: Science, Metaphysics, and the Laws of Nature, Marc Lange has presented an engagingly written, tightly argued, and novel philosophical account of the laws of nature. One of the intuitions behind the notion of a law of nature is, roughly, that of the many regularities we observe in the world there are some which appear to be due to mere happen-stance (“accidental” regularities, in the philosopher’s jargon), while others, which we call “laws,” seem to be possessed of (...) a degree of necessity. For example, if the only music ever to come out of my stereo system during the entirety of its existence were that of James Brown, we would term this an accidental regularity: it seems that it could have been otherwise had the world been different, perhaps by the stereo having a different owner or my having different tastes. On the other hand, the various relations and properties that determine the electrical functioning of my stereo seem more necessary and lawlike: presumably Ohm’s law would have held even had my stereo never been built.1 But even if Ohm’s law is somehow necessary, it seems less necessary than other “broadly logical” truths. Certainly Ohm’s law could have been different, perhaps by a factor of two, yet it seems unreasonable to say that the number 6 could have been prime. Although many philosophers, and certainly most scientists, will readily agree that there is a difference between logical, law-like, and accidental regularities, spelling out the nature of this difference has proved a remarkably difficult task. It is precisely this puzzle which Lange intends Laws and Lawmakers to address. In this review I shall first give a quick and broad outline of Lange’s account of natural laws as I understand it, followed by a brief summary of the contents of the book, and then close with a few critical comments. (shrink)

Imperialism is thought to be wrong by virtually everyone today. The consensus may be correct. However, there may be a few good things to be said for empire. More importantly for political philosophy, empires are not harder to justify or legitimate than states, or so I argue. The bad press that empires receive seems due to a methodological suspect comparison of nasty empires to nice states. When nice empires are considered they do not fare much worse than (nice) states. I (...) suggest that empires can have the same weak kind of legitimacy that states have and that both lack fuller or stronger legitimacy. a Footnotesa An earlier version of this essay was presented at James Madison University and discussed at a workshop of the Committee for Politics, Philosophy, and Public Policy at the University of Maryland, College Park. I am grateful to members of both audiences for critical questions and comments, in particular to John Brown, Farid Dhanji, Douglas Grob, Peter Levine, Jerry Segal, and Karol Soltan (others are thanked in the notes). Gratitude is also owed to Jose Idler-Acosta, David Lefkowitz, and Ellen Paul for helpful written comments. (shrink)

This essay examines several recent philosophical attempts to define ‘disease’. Two prominent ones are considered in detail, an objective approach by Christopher Boorse and a normative approach by Caroline Whitbeck. Both are found to be inadequate for a variety of reasons, though Whitbeck's is superior because of her careful preliminary distinctions and because of its normative approach which is more nearly in accord with medical and lay usage. The paper concludes with a discussion of the nature of such efforts (...) at definition and suggests that their limitations are due both to the nature of our language and concepts in general, and to the nature of medicine in particular. It is the practical and changing character of medicine and its language that frustrates the efforts of philosophers to formulate such definitions. Keywords: disease, definition CiteULike Connotea Del.icio.us What's this? (shrink)

Christopher Miles Coope offers a letter, drafted by Helen Taylor but certified by Mill, in which Mill asserts the duty to vote, as evidence that he could not have regarded harmfulness to others as a necessary condition of moral wrongness. But it is clear that Mill regarded the duty to vote as one of imperfect obligation, and the wrongness of not fulfilling it as a matter roughly of not doing enough, in this case not doing one's fair share. He (...) has room for the common-sense harmlessness of staying at home. At the same time he grounds political duties in the harmfulness of neglecting the power of legislation and in the possibility, consistently maintained, that one can harm by inaction. Mill's view, central to his relation between morality and liberty, remains at work here, while also suggesting reflections on the peculiarity of his conception of harm. (shrink)

A dual referent approach to colour theory maintains that colour names have two intended, equally legitimate referents. For example, one might argue that ‘red’ refers both to red appearances or qualia, and also to the way red objects reflect light, the spectral surface reflectance properties of red things. I argue that normal cases of perceptual relativity can be used to support a dual referent approach, yielding an understanding of colour whose natural extension includes abnormal cases of perceptual relativity. This contrasts (...) with Peacocke’s multi-referent view, according to which such abnormal cases force us to introduce a wholly distinct kind of colour experience. I also argue that the two uses of colour names, arising from their two referents, have different extensions, even in normal perceptual circumstances, a consequence which conflicts with the heart of Rosenthal’s dual referent view. (shrink)

My aim in this paper is to elucidate Leibniz’s account of moral normativity and the relation between motivation and obligation. I argue against the recent interpretation of Christopher Johns, according to which Leibniz’s moral theory is actually a deontological theory, having more in common with Kantian moral theory than with any form of consequentialism. I argue that for Leibniz reason is not itself the source of practical normativity and real obligation; the source of that is rather the agent’s desire (...) for his own happiness or perfection. For Leibniz, reason in its practical role functions instrumentally: the desire for one’s own happiness is the source of practical normativity, and reason functions only to transfer that normativity from the end that it does not determine to the means to those ends that it does determine. (shrink)

Christopher Miles Coope offers a letter, drafted by Helen Taylor but certified by Mill, in which Mill asserts the duty to vote, as evidence that he could not have regarded harmfulness to others as a necessary condition of moral wrongness. But it is clear that Mill regarded the duty to vote as one of imperfect obligation, and the wrongness of not fulfilling it as a matter roughly of not doing enough, in this case not doing one's fair share. He (...) has room for the common-sense harmlessness of staying at home. At the same time he grounds political duties in the harmfulness of neglecting the power of legislation and in the possibility, consistently maintained, that one can harm by inaction. Mill's view, central to his relation between morality and liberty, remains at work here, while also suggesting reflections on the peculiarity of his conception of harm. (shrink)

Three of the articles included in this issue of the Journal of Medicine and Philosophy - Ron Amundson and Shari Tresky's "On a Bioethical Challenge to Disability Rights"; Rachel Cooper's "Can It Be a Good Thing to Be Deaf?"; and Mark T. Brown's "The Potential of the Human Embryo" - interact (in various ways) with the concepts of disability, humanity, and personhood and their normative dimensions. As one peruses these articles, it becomes apparent that terms like "disability," "human being," and (...) "person" carry with them great normative significance. There is, however, much disagreement concerning both the definition and the extension of such terms. This is significant because different terms and definitions are associated with different sets of normative requirements. In what follows we reconstruct the argument of each of the articles, and then offer some brief critical analysis intended to stimulate further thought about and discussion of the issues that each raises. (shrink)

This paper asks whether a necessity can be the source of necessity. According to an influential argument due to Simon Blackburn, it cannot. This paper argues that although Blackburn fails to show that a necessity cannot be the source of necessity, extant accounts fail to establish that it is, with particular focus on Bob Hale’s essentialist theory and Christopher Peacocke’s ‘principle-based’ theory of modality. However, the paper makes some positive suggestions for what a satisfactory answer to the challenge must (...) look like. (shrink)

'Correlations without correlata' is an influential way of thinking of quantum entanglement as a form primitive correlation which nonetheless maintains locality of quantum theory. A number of arguments have sought to suggest that such a view leads either to internal inconsistency or to conflict with the empirical predictions of quantum mechanics. Here wew explicate and provide a partial defence of the notion, arguing that these objections import unwarranted conceptions of correlation properties as hidden variables. A more plausible account sees the (...) properties in terms of Everettian relative states. The ontological robustness of entanglement is also defended from recent objections. (shrink)